Read any comments already posted on the article prior to submission. Submit only on articles published within 6 months of issue date.(Exception: original author replies can include all original authors of the article) Submissions should not have more than 5 authors.(A) A layer 5 (L5) neocortical pyramidal cell with simultaneous patch-clamp recording in the soma (blue), near the middle of the apical dendrite (gray), and near the top of the apical dendrite. Reference 1 must be the article on which you are commenting. Evidence from multi-site patch-clamping, and the intracellular processes inferred from such evidence. Submissions must be You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid If you are responding to a comment that was written about an article you originally authored: Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment. You must have updated your disclosures within six months: If you are uploading a letter concerning an article: © 1974 by the American Academy of Neurology.Limitations of the Golgi method may account for failure to detect abnormalities in less retarded patients and in older patients. The results suggest that defective growth of cortical dendrites is common in the severely retarded. The method failed to detect abnormalities in frontal cortex from several older retarded individuals. Horizontal and tangential branches of apical dendrites also were reduced in number and length. Histologic abnormalities included decrease in length of basal dendrites, decreased secondary branches, and-in the miost severely affected-a decrease in branches arising directly frorn the perikaryon. Four had a history of infantile spasms and an EEG tracing characterized as “hypsarrhythmia” in addition to amentia. Abnormalities in dendritic development were found in five profoundly retarded children at ages one to four years. The Golgi-Cox method was used to analyze the dendritic spread of pyramidal neurons in middle frontal gyrus of 11 patients with mental defect.
0 kommentar(er)
